Cancer
patients undergoing chemotherapy experience high rates of dose-limiting
morbidity. Recently, short-term fasting prior to chemotherapy was shown
to decrease toxicity. In the following paper, the researchers report
that fasting protects multiple small intestinal stem cell populations
marked by Lgr5, Bmi1, or HopX expression and maintains barrier function
to preserve small intestinal architecture from lethal DNA damage. Their
findings provide insight into how fasting protects the host from
toxicity associated with high-dose chemotherapy.
Read the whole paper here:
Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival.
No comments:
Post a Comment